BDBM247863 US10112931, Example 470::US9434719, 470

SMILES C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)ncc1F

InChI Key InChIKey=GRPUGQNJIJGTSU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 247863   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandPNGBDBM247863(US9434719, 470 | US10112931, Example 470)
Affinity DataIC50: 12.8nMpH: 7.4 T: 2°CAssay Description:The biochemical reactions were performed at room temperature in 384-well Greiner flat-bottom plates (Costar, Cat. No. 781201) using a final reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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LigandPNGBDBM247863(US9434719, 470 | US10112931, Example 470)
Affinity DataIC50: 12.8nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent