BDBM247661 US10112931, Example 263::US9434719, 263 as TFA salt::US9688672, Example 263

SMILES C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C2(C)CC2)ncc1F

InChI Key InChIKey=MGAMZOLBMBPWEM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 247661   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandPNGBDBM247661(US9688672, Example 263 | US9434719, 263 as TFA sal...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

LigandPNGBDBM247661(US9688672, Example 263 | US9434719, 263 as TFA sal...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+(NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
Go to US Patent

LigandPNGBDBM247661(US9688672, Example 263 | US9434719, 263 as TFA sal...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent