BDBM24759 2-[amino(phenyl)methyl]-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methyl-3,4-dihydropyrimidin-4-one::pyrimidone, 37

SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(N)c4ccccc4)n(C)c3=O)c2cc1OC

InChI Key InChIKey=CFZUQQDNJOFAHF-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24759   

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM24759(2-[amino(phenyl)methyl]-5-{4-[(6,7-dimethoxyquinol...)
Affinity DataIC50: 72nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM24759(2-[amino(phenyl)methyl]-5-{4-[(6,7-dimethoxyquinol...)
Affinity DataKi:  72nM ΔG°:  -9.64kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2008
Entry Details Article
PubMed