BDBM247327 US9447091, 5

SMILES Cn1cc(cn1)-c1ccc2n(cnc2c1)-c1cc(NS(=O)(=O)C2CC2)cc(c1)-c1ccc(F)cc1F

InChI Key InChIKey=ZJFCBQXPTQSTCZ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 247327   

TargetFibroblast growth factor receptor 1(Human)
Orion

US Patent
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 12nMAssay Description:Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Orion

US Patent
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant FGFR3 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant FGFR4 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant VEGFR1 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant VEGFR3 (unknown origin) in the presence of [p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor substrate 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 93nMAssay Description:Inhibition of FRS2 phosphorylation at Tyr196 residue in human NCI-H1581 cells incubated for 20 mins by electrochemiluminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor substrate 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 59nMAssay Description:Inhibition of FRS2 phosphorylation at Tyr196 residue in human SNU-16 cells incubated for 20 mins by electrochemiluminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor substrate 2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM247327(US9447091, 5)
Affinity DataIC50: 89nMAssay Description:Inhibition of FRS2 phosphorylation at Tyr196 residue in human RT-4 cells incubated for 20 mins by electrochemiluminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed