BDBM247218 US9434733, methyl 5-[[3-methyl-4-(4-oxo-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-2-yl)pyrrolidin-1-yl]methyl]thiophene-2-carboxylate::US9533992, methyl 5-[[3-methyl-4-(4-oxo-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-2-yl)pyrrolidin-1-yl]methyl]thiophene-2-carboxylate

SMILES COC(=O)c1ccc(CN2CC(C)C(C2)c2nn3c(ncc3c(=O)[nH]2)C2CCOCC2)s1

InChI Key InChIKey=ZGEBBGQCOLCUSL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 247218   

LigandPNGBDBM247218(US9434733, methyl 5-[[3-methyl-4-(4-oxo-7-tetrahyd...)
Affinity DataIC50: 8nMT: 2°CAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

LigandPNGBDBM247218(US9434733, methyl 5-[[3-methyl-4-(4-oxo-7-tetrahyd...)
Affinity DataIC50: 8nMpH: 7.6 T: 2°CAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
Go to US Patent

LigandPNGBDBM247218(US9434733, methyl 5-[[3-methyl-4-(4-oxo-7-tetrahyd...)
Affinity DataIC50: 8nMpH: 7.6 T: 2°CAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2018
Entry Details
Go to US Patent