BDBM247186 US9434733, 2-[4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

SMILES CC1CN(Cc2ccc3nccnc3c2)CC1c1nn2c(ncc2c(=O)[nH]1)C1CCOCC1

InChI Key InChIKey=OMZYWFZESJTRNA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 247186   

LigandPNGBDBM247186(US9434733, 2-[4-methyl-1-(quinoxalin-6-ylmethyl)py...)
Affinity DataIC50: 24nMT: 2°CAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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LigandPNGBDBM247186(US9434733, 2-[4-methyl-1-(quinoxalin-6-ylmethyl)py...)
Affinity DataIC50: 24nMpH: 7.6 T: 2°CAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
Go to US Patent

LigandPNGBDBM247186(US9434733, 2-[4-methyl-1-(quinoxalin-6-ylmethyl)py...)
Affinity DataIC50: 24nMpH: 7.6 T: 2°CAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2018
Entry Details
Go to US Patent