BDBM246968 (S)-3-(2-chloro-3-(trifluoromethyl)phenyl)-5-methyl-8-(4-methylpyridin-2-yl)-5,6-dihydrobis([1,2,4]triazolo)[4,3-a:3′,4′-c]pyrazine::US10053463, 125

SMILES C[C@H]1Cn2c(nnc2-c2cc(C)ccn2)-c2nnc(-c3cccc(c3Cl)C(F)(F)F)n12

InChI Key InChIKey=KOVCDCNVGPVAHB-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 246968   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246968((S)-3-(2-chloro-3-(trifluoromethyl)phenyl)-5-methy...)
Affinity DataIC50: 1.60nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246968((S)-3-(2-chloro-3-(trifluoromethyl)phenyl)-5-methy...)
Affinity DataIC50: 7.20nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246968((S)-3-(2-chloro-3-(trifluoromethyl)phenyl)-5-methy...)
Affinity DataKi:  10.5nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246968((S)-3-(2-chloro-3-(trifluoromethyl)phenyl)-5-methy...)
Affinity DataKi:  10.5nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent