BDBM246946 (5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-methyl-8-(1H-pyrazol-3-yl)-5,6-dihydrobis[1,2,4]triazolo[4,3-a:3′,4′-c]pyrazine::US10053463, 103

SMILES C[C@H]1Cn2c(nnc2-c2nnc(-c3cccc(c3Cl)C(F)(F)F)n12)-c1cc[nH]n1

InChI Key InChIKey=SPSUZMVNWVFTSS-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 246946   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246946((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataIC50: 2.5nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246946((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataIC50: 31.8nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246946((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataKi:  22.4nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246946((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataKi:  22.4nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent