BDBM246894 4-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrimidin-1-yl)ethyl]- 5-chloro-2-ethoxy-6- fluorophenyl}pyrrolidin- 2-one::US10053465, 32::US11136326, Example 32d::US9730939, Example 348
SMILES CCOc1c(cc(Cl)c(F)c1C1CNC(=O)C1)C(C)n1nc(C)c2c(N)ncnc12
InChI Key InChIKey=ZQPDJCIXJHUERQ-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 246894
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform(Human)
Incyte Holdings
US Patent
Incyte Holdings
US Patent
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform(Human)
Incyte Holdings
US Patent
Incyte Holdings
US Patent
Affinity DataIC50: 125nMpH: 6.7 T: 2°CAssay Description:Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 125nMAssay Description:In some embodiments, the PI3Kδ inhibitor is selective. By selective is meant that the compound binds to or inhibits a kinase with greater affini...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 125nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 125nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 125nMAssay Description:The IC50s obtained by the method of Assay A at 1 mM ATP as described in the US Patent Publications.More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 50nMAssay Description:The IC50s obtained by the method of Assay A at 1 mM ATP as described in the US Patent Publications.More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 50nMAssay Description:The IC50s obtained by the method of Assay A at 1 mM ATP as described in the US Patent Publications.More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: 125nMAssay Description:The IC50s obtained by the method of Assay A at 1 mM ATP as described in the US Patent Publications.More data for this Ligand-Target Pair