BDBM246891 4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimidin-1-yl)ethyl]- 6-chloro-2-{1-[(2S)-2- hydroxypropyl]azetidin- 3-yl}-3- methoxybenzonitrile::US10053465, 29::US10065963, Compound 29

SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=OLJNDSKWPPNVJJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 246891   

LigandPNGBDBM246891(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 50nMAssay Description:In some embodiments, the PI3Kδ inhibitor is selective. By selective is meant that the compound binds to or inhibits a kinase with greater affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2018
Entry Details
Go to US Patent

LigandPNGBDBM246891(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 100nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

LigandPNGBDBM246891(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 50nMAssay Description: In some embodiments, the PI3Kδ inhibitor is selective. By selective is meant that the compound binds to or inhibits a kinase with greater affin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM246891(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM246891(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Incyte

US Patent
LigandPNGBDBM246891(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 3.00E+3nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent