BDBM246609 (E)-3-(4-Chlorophenyl)-1-{4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl}prop-2-en-1-one::HER2/EGFR dual kinase inhibitor, 7e

SMILES COc1cc2ncnc(Nc3ccc(cc3)C(=O)\C=C\c3ccc(Cl)cc3)c2cc1OC

InChI Key InChIKey=MIFKLWONDMFKNY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246609   

TargetEpidermal growth factor receptor(Human)
Msa University

LigandPNGBDBM246609(HER2/EGFR dual kinase inhibitor, 7e | (E)-3-(4-Chl...)
Affinity DataIC50: 2.58E+3nMAssay Description:Protein kinase assays were performed at ambient temperature for 20-40 min (depending on the target) in a final volume of 25 μl according to the fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Msa University

LigandPNGBDBM246609(HER2/EGFR dual kinase inhibitor, 7e | (E)-3-(4-Chl...)
Affinity DataIC50: 9.88E+4nMAssay Description:Protein kinase assays were performed at ambient temperature for 20-40 min (depending on the target) in a final volume of 25 μl according to the fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed