BDBM246602 DNA topoisomerase inhibitor, 4

SMILES COc1ccc(NC(=S)NNC(=O)C2CCNCC2)cc1

InChI Key InChIKey=WQLXWPSTUCIINL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246602   

TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246602(DNA topoisomerase inhibitor, 4)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246602(DNA topoisomerase inhibitor, 4)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed