BDBM246601 DNA topoisomerase inhibitor, 3

SMILES O=C(NNC(=S)Nc1ccccc1)C1CCNCC1

InChI Key InChIKey=HWTSKBFVXGWJPJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246601   

TargetDNA topoisomerase 1(Human)
Medical University

LigandPNGBDBM246601(DNA topoisomerase inhibitor, 3)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandPNGBDBM246601(DNA topoisomerase inhibitor, 3)
Affinity DataIC50: 2.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed