BDBM245750 US9428511, 42

SMILES CC[C@@H]1CN(C[C@@H]1Nc1c(cnn2cc(nc12)-c1ccc2n(C)ncc2c1)C(N)=O)C(=O)C1(CC1)C#N

InChI Key InChIKey=NRQLNHNXRPWLSF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 245750   

TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM245750(US9428511, 42)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM245750(US9428511, 42)
Affinity DataIC50: 4.40nMpH: 7.4 T: 2°CAssay Description:The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
Go to US Patent