BDBM24495 3-(3-fluoro-4-{[2-(morpholin-4-ylcarbonyl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-1-(2-phenylacetyl)thiourea::thieno[3,2-b]pyridine-based inhibitor, 8e

SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)C(=O)N1CCOCC1

InChI Key InChIKey=OWCRGMTXRLQPSC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24495   

TargetHepatocyte growth factor receptor(Human)
Methylgene

LigandPNGBDBM24495(3-(3-fluoro-4-{[2-(morpholin-4-ylcarbonyl)thieno[3...)
Affinity DataIC50: 125nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2008
Entry Details Article
PubMed
LigandPNGBDBM24495(3-(3-fluoro-4-{[2-(morpholin-4-ylcarbonyl)thieno[3...)
Affinity DataIC50: 289nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2008
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

LigandPNGBDBM24495(3-(3-fluoro-4-{[2-(morpholin-4-ylcarbonyl)thieno[3...)
Affinity DataIC50: 125nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed