BDBM24475 4-{[6-(3,5-difluorophenyl)-[1,2,4]triazolo[4,3-a]pyridazin-3-yl]methoxy}-7-methoxyquinoline::Triazolopyridazine, 10e

SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(F)cc(F)c3)ccnc2c1

InChI Key InChIKey=VGGVRYBMGLIVTI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 24475   

TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM24475(4-{[6-(3,5-difluorophenyl)-[1,2,4]triazolo[4,3-a]p...)
Affinity DataIC50: 7nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM24475(4-{[6-(3,5-difluorophenyl)-[1,2,4]triazolo[4,3-a]p...)
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2008
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM24475(4-{[6-(3,5-difluorophenyl)-[1,2,4]triazolo[4,3-a]p...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM24475(4-{[6-(3,5-difluorophenyl)-[1,2,4]triazolo[4,3-a]p...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of human CYP3A4 in human liver microsomes preincubated with NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM24475(4-{[6-(3,5-difluorophenyl)-[1,2,4]triazolo[4,3-a]p...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed