BDBM244106 US9428491, 1.1::US9428491, 1.1: 2HCl::US9428491, 1.1: naphtalene-1,5-disulfonic acid

SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1nc(c[nH]1)C#CC#Cc1ccc(cc1)-c1c[nH]c(n1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C

InChI Key InChIKey=LFGSEWXATFKDOY-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 244106   

TargetGenome polyprotein [1973-2419](HCV)
TBA

US Patent
LigandPNGBDBM244106(US9428491, 1.1: 2HCl | US9428491, 1.1: naphtalene-...)
Affinity DataIC50: 0.00310nMT: 2°CAssay Description:Solutions of the tested compounds in DMEM medium {DMEM) 1x; Source: Cellgro; Catalogue: 10-013-CV} were prepared immediately before use. Eleven seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [1973-2419](HCV)
TBA

US Patent
LigandPNGBDBM244106(US9428491, 1.1: 2HCl | US9428491, 1.1: naphtalene-...)
Affinity DataIC50: 0.00340nMT: 2°CAssay Description:Solutions of the tested compounds in DMEM medium {DMEM) 1x; Source: Cellgro; Catalogue: 10-013-CV} were prepared immediately before use. Eleven seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [1973-2419](HCV)
TBA

US Patent
LigandPNGBDBM244106(US9428491, 1.1: 2HCl | US9428491, 1.1: naphtalene-...)
Affinity DataIC50: 0.00400nMT: 2°CAssay Description:Solutions of the tested compounds in DMEM medium {DMEM) 1x; Source: Cellgro; Catalogue: 10-013-CV} were prepared immediately before use. Eleven seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM244106(US9428491, 1.1: 2HCl | US9428491, 1.1: naphtalene-...)
Affinity DataIC50: 0.407nMAssay Description:Inhibition of HCV genotype 5a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM244106(US9428491, 1.1: 2HCl | US9428491, 1.1: naphtalene-...)
Affinity DataIC50: 2.45nMAssay Description:Inhibition of HCV genotype 3a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM244106(US9428491, 1.1: 2HCl | US9428491, 1.1: naphtalene-...)
Affinity DataIC50: 0.0280nMAssay Description:Inhibition of HCV genotype 4a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM244106(US9428491, 1.1: 2HCl | US9428491, 1.1: naphtalene-...)
Affinity DataIC50: 0.215nMAssay Description:Inhibition of HCV genotype 1a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM244106(US9428491, 1.1: 2HCl | US9428491, 1.1: naphtalene-...)
Affinity DataIC50: 0.00500nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM244106(US9428491, 1.1: 2HCl | US9428491, 1.1: naphtalene-...)
Affinity DataIC50: 0.0840nMAssay Description:Inhibition of HCV genotype 2a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed