BDBM244039 10-((5-chloro-4-(2-(isopropylsulfonyl)phenyl)aminopyrimidin-2-yl)amino)-9-methoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline)-4-one::US10053458, 97

SMILES COc1cc2CCN3C(CNCC3=O)c2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key InChIKey=LVBJEZPSLPIGDT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 244039   

TargetInsulin receptor(Human)
University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM244039(10-((5-chloro-4-(2-(isopropylsulfonyl)phenyl)amino...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of insulin receptor kinase (unknown origin) using TK as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM244039(10-((5-chloro-4-(2-(isopropylsulfonyl)phenyl)amino...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of wild type ALK (unknown origin) using TK as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor [L1196M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM244039(10-((5-chloro-4-(2-(isopropylsulfonyl)phenyl)amino...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM244039(10-((5-chloro-4-(2-(isopropylsulfonyl)phenyl)amino...)
Affinity DataIC50: 10nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
US Patent