BDBM244025 9-((5-chloro-4-(2-(isopropylsulfonyl)phenyl)aminopyrimidin-2-yl)amino)-10-methoxy-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinoline)-4(11bH)-one::US10053458, 84

SMILES COc1cc2C3CNCC(=O)N3CCc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key InChIKey=XJMFPTCMAYQIDJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 244025   

TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM244025(9-((5-chloro-4-(2-(isopropylsulfonyl)phenyl)aminop...)
Affinity DataIC50: 10nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
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TargetALK tyrosine kinase receptor [L1196M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM244025(9-((5-chloro-4-(2-(isopropylsulfonyl)phenyl)aminop...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM244025(9-((5-chloro-4-(2-(isopropylsulfonyl)phenyl)aminop...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of wild type ALK (unknown origin) using TK as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetInsulin receptor(Human)
University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM244025(9-((5-chloro-4-(2-(isopropylsulfonyl)phenyl)aminop...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of insulin receptor kinase (unknown origin) using TK as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed