BDBM24400 5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine::JMC521864 Compund DSM1::Triazolopyrimidine-Based Compound, 7

SMILES Cc1cc(Nc2ccc3ccccc3c2)n2ncnc2n1

InChI Key InChIKey=WPVMVODGPNYYEV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 24400   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas At Dallas

LigandPNGBDBM24400(JMC521864 Compund DSM1 | 5-methyl-N-(naphthalen-2-...)
Affinity DataIC50: 47nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2008
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas At Dallas

LigandPNGBDBM24400(JMC521864 Compund DSM1 | 5-methyl-N-(naphthalen-2-...)
Affinity DataIC50: 47nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei (strain Anka))
University of Washington At Seattle

LigandPNGBDBM24400(JMC521864 Compund DSM1 | 5-methyl-N-(naphthalen-2-...)
Affinity DataIC50: 230nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395](Human)
University of Washington At Seattle

LigandPNGBDBM24400(JMC521864 Compund DSM1 | 5-methyl-N-(naphthalen-2-...)
Affinity DataIC50: 2.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
State Key Laboratory of Bioreactor Engineering

Curated by ChEMBL
LigandPNGBDBM24400(JMC521864 Compund DSM1 | 5-methyl-N-(naphthalen-2-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of Plasmodium falciparum DHODH (Phe158 to Ser569) expressed in Escherichia coli BL21 using dihydroorotate as substrate measured every 30 s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas At Dallas

LigandPNGBDBM24400(JMC521864 Compund DSM1 | 5-methyl-N-(naphthalen-2-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of Plasmodium falciparum recombinant N-terminal His6-tagged DHODH (159-569 residues) expressed in Escherichia coli BL21(DE3) using DHO as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM24400(JMC521864 Compund DSM1 | 5-methyl-N-(naphthalen-2-...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human DHODH expressed in Escherichia coli by DCIP staining-based spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed