BDBM243382 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-methoxy-2,3-dihydro-1H-spiro[cyclopentane-1,4-isoquinoline]-6-yl)pyrimidine-2,4-diamine::US10053458, 14

SMILES COc1cc2CNCC3(CCCC3)c2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key InChIKey=IGKXCHBECNDTQI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 243382   

TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243382(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-me...)
Affinity DataIC50: 1nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM243382(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-me...)
In Depth
Date in BDB:
10/18/2018
Entry Details
US Patent