BDBM243272 3-(3,5-dimethyl-4- isoxazolyl)-7-((4-hydroxy- 2,2,6,6-tetramethyl-1- piperidinyl)carbonyl)-9- (methylsulfonyl)-9H- carbazole-1-carboxamide::US10053454, Example 16::US10196387, Example 16

SMILES Cc1noc(C)c1-c1cc(C(N)=O)c2n(c3cc(ccc3c2c1)C(=O)N1C(C)(C)CC(O)CC1(C)C)S(C)(=O)=O

InChI Key InChIKey=LPMSTWXCQFMNRT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 243272   

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243272(3-(3,5-dimethyl-4- isoxazolyl)-7-((4-hydroxy- 2,2,...)
Affinity DataIC50: 50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243272(3-(3,5-dimethyl-4- isoxazolyl)-7-((4-hydroxy- 2,2,...)
Affinity DataIC50: 50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243272(3-(3,5-dimethyl-4- isoxazolyl)-7-((4-hydroxy- 2,2,...)
Affinity DataIC50: 50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details
Go to US Patent