BDBM243270 3-(3,5-dimethyl-4- isoxazolyl)-7-((3-methoxy- 1-azetidinyl)carbonyl)-9- (methylsulfonyl)-9H- carbazole-1-carboxamide::US10053454, Example 14::US10196387, Example 14

SMILES COC1CN(C1)C(=O)c1ccc2c(c1)n(c1c(cc(cc21)-c1c(C)noc1C)C(N)=O)S(C)(=O)=O

InChI Key InChIKey=XXMAVZMQJLUVRH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 243270   

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243270(3-(3,5-dimethyl-4- isoxazolyl)-7-((3-methoxy- 1-az...)
Affinity DataIC50: 50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243270(3-(3,5-dimethyl-4- isoxazolyl)-7-((3-methoxy- 1-az...)
Affinity DataIC50: 50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243270(3-(3,5-dimethyl-4- isoxazolyl)-7-((3-methoxy- 1-az...)
Affinity DataIC50: 50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details
Go to US Patent