BDBM24306 Letrozole derivative, 40::{2-bromo-4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl]phenyl} sulfamate

SMILES NS(=O)(=O)Oc1ccc(cc1Br)C(c1ccc(cc1)C#N)n1cncn1

InChI Key InChIKey=SGRBZPZPWNVVPZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 24306   

TargetAromatase(Human)
University of Bath

LigandPNGBDBM24306({2-bromo-4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)...)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24306({2-bromo-4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)...)
Affinity DataIC50: 2.60E+3nMAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24306({2-bromo-4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of STS activity (unknown origin) expressed in JEG-3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24306({2-bromo-4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of aromatase (unknown origin) expressed in JEG-3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandPNGBDBM24306({2-bromo-4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of aromatase in human JEG-3 cells using [1beta-3H]androstenedione as substrate after 1 hr by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

LigandPNGBDBM24306({2-bromo-4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of steroid sulfatase in human JEG-3 cells using [6,7-3H]E1S as substrate after 1 hr by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed