BDBM242376 US10047093, 8-33::US10392392, Example 8-33::US10875864, EX. 8-33::US9416132, 8-33

SMILES FC(F)(F)c1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12

InChI Key InChIKey=SSXPZXJQITXPKU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 242376   

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM242376(US10047093, 8-33 | US9416132, 8-33 | US10392392, E...)
Affinity DataIC50: 33nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM242376(US10047093, 8-33 | US9416132, 8-33 | US10392392, E...)
Affinity DataIC50: 33nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM242376(US10047093, 8-33 | US9416132, 8-33 | US10392392, E...)
Affinity DataIC50: 33nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM242376(US10047093, 8-33 | US9416132, 8-33 | US10392392, E...)
Affinity DataIC50: 33nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent