BDBM241108 US9409895, 19::US9630945, 19

SMILES Clc1cc(Cl)cc(COC(=O)N2CCC(CC2)NC(=O)CCc2c[nH]nn2)c1

InChI Key InChIKey=QUGNOBIRXQGNST-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 241108   

TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM241108(US9409895, 19 | US9630945, 19)
Affinity DataIC50: 3nMAssay Description:ATX activity was determined by measurement of released choline in reactions containing ATX (10 nM), choline oxidase (0.1 U/ml), HRP (100 U/ml), ample...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM241108(US9409895, 19 | US9630945, 19)
Affinity DataIC50: 3nMAssay Description:ATX activity was determined by measurement of released choline in reactions containing ATX (10 nM), choline oxidase (0.1 U/ml), HRP (100 U/ml), ample...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM241108(US9409895, 19 | US9630945, 19)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells at -90 mV holding potential by Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM241108(US9409895, 19 | US9630945, 19)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of ATX (unknown origin) assessed as decrease in choline releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMed