BDBM24053 3-(2,5-difluorophenyl)-N,N-dimethyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide::CHEMBL196985::dihydropyrazole, 7

SMILES CN(C)C(=O)N1N=C(CC1c1ccccc1)c1cc(F)ccc1F

InChI Key InChIKey=OJTLBPPHFFUINF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24053   

LigandPNGBDBM24053(CHEMBL196985 | 3-(2,5-difluorophenyl)-N,N-dimethyl...)
Affinity DataIC50: 84nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2008
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24053(CHEMBL196985 | 3-(2,5-difluorophenyl)-N,N-dimethyl...)
Affinity DataIC50: 84nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24053(CHEMBL196985 | 3-(2,5-difluorophenyl)-N,N-dimethyl...)
Affinity DataIC50: 84nMAssay Description:Inhibition of KSPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed