BDBM24049 1-[3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one::CHEMBL365108::dihydropyrazole, 3

SMILES CC(=O)N1N=C(CC1c1ccccc1)c1cc(F)ccc1F

InChI Key InChIKey=KZGOVHLBKDLTGK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24049   

LigandPNGBDBM24049(CHEMBL365108 | 1-[3-(2,5-difluorophenyl)-5-phenyl-...)
Affinity DataIC50: 94nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2008
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24049(CHEMBL365108 | 1-[3-(2,5-difluorophenyl)-5-phenyl-...)
Affinity DataIC50: 94nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed