BDBM23973 3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydrochloride::amino-tetralone, 1

SMILES NC1Cc2ccccc2CC1=O

InChI Key InChIKey=YGVHQWKMQXSMHD-UHFFFAOYSA-N

Data  4 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 23973   

TargetCytosol aminopeptidase(Bovine)
Enscmu

LigandPNGBDBM23973(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Affinity DataIC50: 1.20E+5nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetBacterial leucyl aminopeptidase(Vibrio proteolyticus)
Enscmu

LigandPNGBDBM23973(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Affinity DataIC50: 1.30E+5nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Enscmu

LigandPNGBDBM23973(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Affinity DataIC50: 500nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Enscmu

LigandPNGBDBM23973(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Affinity DataIC50: 1.00E+6nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Bovine)
Enscmu

LigandPNGBDBM23973(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Enscmu

LigandPNGBDBM23973(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of aminopeptidase activity of human leukotriene A4 hydrolase by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Merck Sharpe and Dohme

Curated by ChEMBL
LigandPNGBDBM23973(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Affinity DataKi:  500nMAssay Description:Inhibition of human aminopeptidase N by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Merck Sharpe and Dohme

Curated by ChEMBL
LigandPNGBDBM23973(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Affinity DataKi:  500nMAssay Description:Inhibition of APNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Enscmu

LigandPNGBDBM23973(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Affinity DataKi:  1.20E+5nMAssay Description:Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Bovine)
Enscmu

LigandPNGBDBM23973(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Affinity DataKi: >1.00E+6nMAssay Description:Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed