BDBM238983 US9403846, 1

SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CCCO1)c1ccc(F)cc1F

InChI Key InChIKey=AYIXLNDRJRRIAH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 238983   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM238983(US9403846, 1)
Affinity DataIC50: 447nMpH: 4.5Assay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent

TargetBeta-secretase 2 [21-466](Human)
Pfizer

US Patent
LigandPNGBDBM238983(US9403846, 1)
Affinity DataIC50: 1.29E+3nMpH: 4.5 T: 2°CAssay Description:A synthetic substrate that can be cleaved by BACE2 having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Green at the Cy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent