BDBM238975 US9403833, 10::US9403833, 12

SMILES Cc1c(NC(=O)c2nnn(c2C)-c2ccc(cc2Cl)C2CC2)c(=O)n(C2CCCCC2)n1C

InChI Key InChIKey=DJCHYTWZRDUVHQ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 238975   

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM238975(US9403833, 12 | US9403833, 10)
Affinity DataIC50: 92nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM238975(US9403833, 12 | US9403833, 10)
Affinity DataIC50: 98nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM238975(US9403833, 12 | US9403833, 10)
Affinity DataEC50:  316nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF2(Homo sapiens)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM238975(US9403833, 12 | US9403833, 10)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SMURF2 (unknown origin) assessed as self-ubiquitination by TR-FRET/biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed