BDBM237391 US9393232, 1.1::US9393232, 1.1a::US9393232, 1.1b

SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccccc1

InChI Key InChIKey=XJPHRHZKIAVBTN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 237391   

TargetBromodomain-containing protein 4 [1-477](Human)
Beigene

US Patent
LigandPNGBDBM237391(US9393232, 1.1 | US9393232, 1.1a | US9393232, 1.1b)
Affinity DataIC50: 51nMpH: 7.5Assay Description:The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [1-477](Human)
Beigene

US Patent
LigandPNGBDBM237391(US9393232, 1.1 | US9393232, 1.1a | US9393232, 1.1b)
Affinity DataIC50: 35nMpH: 7.5Assay Description:The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [1-477](Human)
Beigene

US Patent
LigandPNGBDBM237391(US9393232, 1.1 | US9393232, 1.1a | US9393232, 1.1b)
Affinity DataIC50: 7.00E+3nMpH: 7.5Assay Description:The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM237391(US9393232, 1.1 | US9393232, 1.1a | US9393232, 1.1b)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged BRD4 (1 to 477 residues) expressed in Escherichia coli using tetra-acetylated histone peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed