BDBM23725 3,4,5-trimethyl-1-[(3,4,5-trimethoxyphenyl)carbonyl]-1H-pyrazole::N-Benzoylpyrazole deriv., 33

SMILES COc1cc(cc(OC)c1OC)C(=O)n1nc(C)c(C)c1C

InChI Key InChIKey=ZQCWCMVYVBHUNF-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23725   

TargetChymotrypsin-C(Human)
Montana State University

LigandPNGBDBM23725(3,4,5-trimethyl-1-[(3,4,5-trimethoxyphenyl)carbony...)
Affinity DataIC50: 5.60E+3nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
Montana State University

LigandPNGBDBM23725(3,4,5-trimethyl-1-[(3,4,5-trimethoxyphenyl)carbony...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Montana State University

LigandPNGBDBM23725(3,4,5-trimethyl-1-[(3,4,5-trimethoxyphenyl)carbony...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Montana State University

LigandPNGBDBM23725(3,4,5-trimethyl-1-[(3,4,5-trimethoxyphenyl)carbony...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Montana State University

LigandPNGBDBM23725(3,4,5-trimethyl-1-[(3,4,5-trimethoxyphenyl)carbony...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetCathepsin D(Human)
Montana State University

LigandPNGBDBM23725(3,4,5-trimethyl-1-[(3,4,5-trimethoxyphenyl)carbony...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Montana State University

LigandPNGBDBM23725(3,4,5-trimethyl-1-[(3,4,5-trimethoxyphenyl)carbony...)
Affinity DataKi:  5.09E+4nM ΔG°:  -5.85kcal/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed