BDBM23712 1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole::N-Benzoylpyrazole deriv., 20

SMILES Cc1ccccc1C(=O)n1cc(cn1)[N+]([O-])=O

InChI Key InChIKey=ORXYMBYYSLQOLK-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23712   

TargetChymotrypsin-C(Human)
Montana State University

LigandPNGBDBM23712(1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole |...)
Affinity DataIC50: 240nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
Montana State University

LigandPNGBDBM23712(1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole |...)
Affinity DataIC50: 1.21E+4nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Montana State University

LigandPNGBDBM23712(1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole |...)
Affinity DataIC50: 1.30E+3nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Montana State University

LigandPNGBDBM23712(1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole |...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Montana State University

LigandPNGBDBM23712(1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole |...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetCathepsin D(Human)
Montana State University

LigandPNGBDBM23712(1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole |...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Montana State University

LigandPNGBDBM23712(1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole |...)
Affinity DataKi:  65nM ΔG°:  -9.80kcal/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed