BDBM23701 4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole::N-Benzoylpyrazole deriv., 3

SMILES [O-][N+](=O)c1cccc(c1)C(=O)n1cc(Cl)cn1

InChI Key InChIKey=BKMXGSZQEWHCJH-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23701   

TargetChymotrypsin-C(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataIC50: 340nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataIC50: 680nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataIC50: 170nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataIC50: 1.13E+4nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetCathepsin D(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataKi:  24nM ΔG°:  -10.4kcal/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed