BDBM23700 N-Benzoylpyrazole deriv., 2::methyl 1-[(4-chlorophenyl)carbonyl]-1H-pyrazole-5-carboxylate

SMILES COC(=O)c1ccnn1C(=O)c1ccc(Cl)cc1

InChI Key InChIKey=POSTYOWAJZBEMF-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23700   

TargetChymotrypsin-C(Human)
Montana State University

LigandPNGBDBM23700(methyl 1-[(4-chlorophenyl)carbonyl]-1H-pyrazole-5-...)
Affinity DataIC50: 15nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
Montana State University

LigandPNGBDBM23700(methyl 1-[(4-chlorophenyl)carbonyl]-1H-pyrazole-5-...)
Affinity DataIC50: 51nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Montana State University

LigandPNGBDBM23700(methyl 1-[(4-chlorophenyl)carbonyl]-1H-pyrazole-5-...)
Affinity DataIC50: 120nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Montana State University

LigandPNGBDBM23700(methyl 1-[(4-chlorophenyl)carbonyl]-1H-pyrazole-5-...)
Affinity DataIC50: 1.19E+4nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Montana State University

LigandPNGBDBM23700(methyl 1-[(4-chlorophenyl)carbonyl]-1H-pyrazole-5-...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetCathepsin D(Human)
Montana State University

LigandPNGBDBM23700(methyl 1-[(4-chlorophenyl)carbonyl]-1H-pyrazole-5-...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Montana State University

LigandPNGBDBM23700(methyl 1-[(4-chlorophenyl)carbonyl]-1H-pyrazole-5-...)
Affinity DataKi:  15nM ΔG°:  -10.7kcal/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed