BDBM236558 US9365572, 6

SMILES Cn1c(=O)n(-c2cccc(c2)C(F)(F)F)c2c3nc(ccc3ncc2c1=O)-c1ccc(N)nc1

InChI Key InChIKey=MTOZTLWHHAIRTM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 236558   

LigandPNGBDBM236558(US9365572, 6)
Affinity DataIC50: 65.8nMpH: 7.5 T: 2°CAssay Description:Agents: 1-fold kinase buffer: 50 mM HEPES, pH 7.5, 3 mM MgCl2, 1 mM EGTA, 100 mM NaCl, 0.03% CHAPS, 2 mM DTT). 4-fold kinase solution: PI3K ± kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
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TargetSerine/threonine-protein kinase mTOR(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM236558(US9365572, 6)
Affinity DataIC50: 5.40nMpH: 7.5 T: 2°CAssay Description:Agents: 1-fold kinase buffer: 50 mM HEPES, pH 7.5, 10 mM MgCl2, 1 mM EGTA, 3 mM MnCl2, 0.01% Tween-20, 2 mM DTT. 4-fold kinase solution: mTOR kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent