BDBM235778 US9359372, DC037030
SMILES COc1cc2CCN3Cc4c(OC)ccc(OC)c4C[C@H]3c2cc1O
InChI Key InChIKey=QTZLXFFBWVRFEC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 235778
TargetD(1A) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 1.90E+3nMpH: 7.5Assay Description:For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containin...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataKi: 3.70nM ΔG°: -11.7kcal/mole IC50: 7.22nMT: 2°CAssay Description:Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as recepto...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataKi: 3.70nM ΔG°: -11.7kcal/molepH: 7.4 T: 2°CAssay Description:The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were s...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataKi: 493nM ΔG°: -8.74kcal/mole IC50: 626nMT: 2°CAssay Description:Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as recepto...More data for this Ligand-Target Pair