BDBM23526 2-{3-[1-(4-hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl]propanamido}benzoic acid::Biaryl Anthranilide Analogue, 2h::CHEMBL236163

SMILES Cc1c(CCC(=O)Nc2ccccc2C(O)=O)cnn1-c1ccc(O)cc1

InChI Key InChIKey=JKDSYBSOELYDQY-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23526   

TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23526(2-{3-[1-(4-hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 24nM EC50:  93nMpH: 7.4 T: 2°CAssay Description:Membranes were incubated in binding buffer with [5, 6-3H]-niacin in the presence of test compound. After 4 hours at room temperature, reactions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2008
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM23526(2-{3-[1-(4-hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM23526(2-{3-[1-(4-hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM23526(2-{3-[1-(4-hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM23526(2-{3-[1-(4-hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23526(2-{3-[1-(4-hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl...)
Affinity DataEC50:  93nMAssay Description:Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23526(2-{3-[1-(4-hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 24nMAssay Description:Displacement of [3H]niacin from GRP109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed