BDBM235026 4-(1-(2-chloro-6-(1-hydroxycyclobutyl)benzyl)-4-fluoro-1H-indazol-3-yl)-3-fluorobenzoic acid (7A)::US9556168, 7A

SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)cccc3C3(O)CCC3)c3cccc(F)c23)c(F)c1

InChI Key InChIKey=CDFNKXNAPBCTQM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 235026   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM235026(4-(1-(2-chloro-6-(1-hydroxycyclobutyl)benzyl)-4-fl...)
Affinity DataIC50: 380nMpH: 7.0Assay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent