BDBM23500 4-({[4-(but-2-yn-1-yloxy)benzene]sulfonyl}methyl)-N-hydroxy-1-(propane-2-sulfonyl)piperidine-4-carboxamide::CHEMBL209970::beta-sulfonyl hydroxamate analogue, 4

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)CC1(CCN(CC1)S(=O)(=O)C(C)C)C(=O)NO

InChI Key InChIKey=CEVLUPQNDFOYSI-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 23500   

TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 230nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
The M. S. University of Baroda

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 8.78E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 355nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 230nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
The M. S. University of Baroda

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
The M. S. University of Baroda

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of TACE in human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 230nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 355nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 8.78E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
The M. S. University of Baroda

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
The M. S. University of Baroda

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 8.78E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 355nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 4.71E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 4.71E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 3.64E+3nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 157nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 280nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed