BDBM234860 US9353116, 19::US9353116, Fig. 16, Compound 1

SMILES COc1cc2ncnc(Nc3cccc(NS(=O)(=O)C=C)c3)c2cc1OC

InChI Key InChIKey=XWEWXOXVGICYJP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 234860   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of California

US Patent
LigandPNGBDBM234860(US9353116, Fig. 16, Compound 1 | US9353116, 19)
Affinity DataIC50: 213nMAssay Description:In vitro kinase assays using LRRK WT and LRRK G2019S.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
University of California

US Patent
LigandPNGBDBM234860(US9353116, Fig. 16, Compound 1 | US9353116, 19)
Affinity DataIC50: 45.5nMAssay Description:In vitro kinase assays using LRRK WT and LRRK G2019S.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src [251-533](Chicken)
University of California

US Patent
LigandPNGBDBM234860(US9353116, Fig. 16, Compound 1 | US9353116, 19)
Affinity DataIC50: 5.00E+3nMpH: 8.0Assay Description:In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338C](Chicken)
University of California

US Patent
LigandPNGBDBM234860(US9353116, Fig. 16, Compound 1 | US9353116, 19)
Affinity DataIC50: 1.00E+3nMpH: 8.0Assay Description:In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent