BDBM234541 US9353089, 275

SMILES COc1ccc(cc1)C1(NC(=N)N(CC2CCOCC2)C1=O)c1ccc(OC)cc1

InChI Key InChIKey=KKROSRYNPGAQGH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 234541   

TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234541(US9353089, 275)
Affinity DataIC50: 17nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
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TargetPlasmepsin IV [1-448](malaria parasite P. falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234541(US9353089, 275)
Affinity DataIC50: 59nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Saint Louis University

US Patent
LigandPNGBDBM234541(US9353089, 275)
Affinity DataIC50: 2.07E+3nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetCathepsin D(Human)
Saint Louis University

US Patent
LigandPNGBDBM234541(US9353089, 275)
Affinity DataIC50: 934nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetCathepsin E(Human)
Saint Louis University

US Patent
LigandPNGBDBM234541(US9353089, 275)
Affinity DataIC50: 841nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234541(US9353089, 275)
Affinity DataIC50: 16.9nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Saint Louis University

US Patent
LigandPNGBDBM234541(US9353089, 275)
Affinity DataIC50: 2.07E+3nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent