BDBM234497 US9353089, 117

SMILES COc1ccc(cc1)C1(NC(=N)N(C2CCCCC2)C1=O)c1ccc(OC)cc1

InChI Key InChIKey=QFSACLHXUZDWGE-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 234497   

TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetPlasmepsin IV [1-448](malaria parasite P. falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 15nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 1.20E+4nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetCathepsin D(Human)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 1.00E+4nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetCathepsin E(Human)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 1.19E+3nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The cytochrome P450 inhibitory potentials of compounds for human recombinant CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A were determined using Vivid C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 5.48E+3nMT: 2°CAssay Description:The cytochrome P450 inhibitory potentials of compounds for human recombinant CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A were determined using Vivid C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The cytochrome P450 inhibitory potentials of compounds for human recombinant CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A were determined using Vivid C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 449nMT: 2°CAssay Description:The cytochrome P450 inhibitory potentials of compounds for human recombinant CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A were determined using Vivid C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 3.96nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Saint Louis University

US Patent
LigandPNGBDBM234497(US9353089, 117)
Affinity DataIC50: 1.20E+4nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
Go to US Patent