BDBM234341 4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydrazinyl)phenyl)-5-phenyl-N-(5-sulphamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide (11)

SMILES [#6]-[#6](=O)-[#6](=[#7]\[#7]-c1ccc(cc1)-n1nc(-[#6](=O)-[#7]-c2nnc(s2)S([#7])(=O)=O)c(-[#6](=O)-c2ccccc2)c1-c1ccccc1)\[#6](-[#6])=O

InChI Key InChIKey=LQIGBCNHEUVEAQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 234341   

TargetCarbonic anhydrase 1(Human)
Dumlupinar University

LigandPNGBDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 330nMAssay Description:Carbonic anhydrase (CA) activity was assayed by following the hydration of CO2 according to the method described by Wilbur and Anderson [Wilbur et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Dumlupinar University

LigandPNGBDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 80nMAssay Description:Carbonic anhydrase (CA) activity was assayed by following the hydration of CO2 according to the method described by Wilbur and Anderson [Wilbur et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Dumlupinar University

LigandPNGBDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 570nMpH: 7.4Assay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Dumlupinar University

LigandPNGBDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 130nMpH: 7.4Assay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Dumlupinar University

LigandPNGBDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 572nMAssay Description:The Ki values were determined as described in the literature [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; B lb l et al., J. Enzyme I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Dumlupinar University

LigandPNGBDBM234341(4-Benzoyl-1-(4-(2-(2,4-dioxopentan-3-ylidene)hydra...)
Affinity DataIC50: 103nMAssay Description:The Ki values were determined as described in the literature [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; B lb l et al., J. Enzyme I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed