BDBM232604 US9346815, 150

SMILES CC(=O)NCCCN1CCC(CC1)n1cc(NC(=O)C(\C(N)=N)=C2\NC=CC=N2)c(n1)-c1cc(Cl)ccc1OC(F)F

InChI Key InChIKey=VESWGANAAGWUKR-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 232604   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM232604(US9346815, 150)
Affinity DataKi:  0.170nM ΔG°:  -13.2kcal/molepH: 7.2 T: 2°CAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM232604(US9346815, 150)
Affinity DataKi:  0.730nM ΔG°:  -12.3kcal/molepH: 7.2 T: 2°CAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details
Go to US Patent