BDBM23140 US8846658, 144::US8846658, 147

SMILES Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@@]1(COCC(N)=N1)C(F)F)C#N

InChI Key InChIKey=DHIZXRDJXNCTKQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 23140   

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM23140(US8846658, 144 | US8846658, 147)
Affinity DataIC50: 79nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM23140(US8846658, 144 | US8846658, 147)
Affinity DataIC50: 17nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM23140(US8846658, 144 | US8846658, 147)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain in presence of FRET substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM23140(US8846658, 144 | US8846658, 147)
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed