BDBM231252 US10092556, Comparative Example 6::US9346787, Comparative Example 6

SMILES Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)C(O)=O)ccc2C#N)n[nH]1

InChI Key InChIKey=CTWASZOPAJRLED-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 231252   

TargetAurora kinase A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM231252(US9346787, Comparative Example 6 | US10092556, Com...)
Affinity DataIC50: 220nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM231252(US9346787, Comparative Example 6 | US10092556, Com...)
Affinity DataIC50: 320nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM231252(US9346787, Comparative Example 6 | US10092556, Com...)
Affinity DataIC50: 220nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM231252(US9346787, Comparative Example 6 | US10092556, Com...)
Affinity DataIC50: 320nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
Go to US Patent