BDBM231228 US9346782, 8

SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(=O)OC(C)(C)C

InChI Key InChIKey=KGQNXXWLTAQQPJ-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 231228   

TargetNuclear receptor ROR-gamma [258-518](Artificial Sequence)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM231228(US9346782, 8)
Affinity DataKd:  3.10E+3nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
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TargetNuclear receptor ROR-gamma [258-518,Y502F](Artificial Sequence)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM231228(US9346782, 8)
Affinity DataIC50: 4.00E+3nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent