BDBM23078 3-(4-phenylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]propan-1-one::CHEMBL227046::alpha-ketooxazole, 11j

SMILES O=C(CCc1ccc(cc1)-c1ccccc1)c1ncc(o1)-c1ccccn1

InChI Key InChIKey=SEFMBCXQEYFZNK-UHFFFAOYSA-N

Data  7 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 23078   

TargetCarboxylic ester hydrolase(Human)
The Scripps Research Institute

LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataIC50: 1.20E+3nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2008
Entry Details Article
PubMed
TargetNeutral cholesterol ester hydrolase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of KIAA1363More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of rat recombinant FAAH expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of TGHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
The Scripps Research Institute

LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataKi:  0.75nM ΔG°:  -12.4kcal/mole IC50: 0.700nMT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2008
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataKi:  0.75nMpH: 9.0Assay Description:Inhibition of FAAH at pH 9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataKi:  0.75nMAssay Description:Inhibition of rat recombinant FAAH expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataKi:  0.75nMAssay Description:Inhibition of rat recombinant FAAH expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataKi:  0.75nMAssay Description:Inhibition of FAAHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataKi:  2.90nM ΔG°:  -11.6kcal/moleT: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2008
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM23078(CHEMBL227046 | 3-(4-phenylphenyl)-1-[5-(pyridin-2-...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human recombinant FAAH expressed COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed